PRS 2008 Meeting
The 2008 meeting of the Perinatal Research Society will be held
September 26-28, 2008 at the
The Bishops
Lodge Ranch Resort & Spa.
Nestled in the majestic Sangre de Cristos, The Bishop's Lodge Ranch Resort &
Spa offers the perfect balance of soothing luxury and exhilarating
recreation in a time-honored setting.
For more
information on the facility and to see pictures of the accommodations,
please visit the Westin's website at
http://www.bishopslodge.com.
The deadline
to register for this year's meeting is Tuesday, August 26th, 2008.
To register for this year's meeting,
click here. You will be routed to our customized online
reservations page for the Bishop's Lodge. The nightly rate will
include the meal package as well as all taxes and fees. The rate for
single occupancy is $360/night and $460/night ($230 per person) for double
occupancy. Those
wanting to share a room or bring a spouse or guest need only to indicate the
number of individuals staying in the room and additional meal packages will
be applied. Spouses and guests may stay with the attendee at no additional
room cost. However, the spouse/guest will purchase a meal plan at the same
rate as an attendee. The room rate of $229/night plus taxes and fees
is available for three days prior to and following the meeting for those
wishing to extend their stay. If you wish to extend your stay at the
Bishop's Lodge, you must contact them directly for reservations at
800.732.2240.
To ensure that attendance is recorded and to receive meeting materials,
please be sure to check in with the Society staff upon arrival.
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2008 Perinatal
Research Society
39th
Annual Meeting
Santa
Fe, New Mexico, United States
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Friday, Sept. 26
Event

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3:00pm – 4:00pm |
President’s Advisory
Council Meeting |
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4:00pm – 5:00pm
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Council Meeting
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4:00pm – 6:00pm
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Check-In and
Registration
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5:30pm – 6:30pm |
Welcome Reception
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6:30pm
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Welcome by PRS President
Yoel Sadovsky
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6:45pm
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LILEY LECTURER
James M. Roberts, MD
Senior Scientist,
Magee-Womens Research
Institute and Professor Obstetrics Gynecology
and Reproductive Sciences and Epidemiology
University of Pittsburgh
Whither
Whither Toxaemia? (Whither
Toxaemia revisited)
Speaker Bio
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8:00pm |
Dinner |

Saturday, Sept. 27
Event

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7:00am - 8:00am
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Young Investigators Meeting - Research
Opportunities for Early Career Investigators
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7:00am - 8:00am
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BREAKFAST
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8:00am
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ABBOTT LECTURER
Terrie Inder, MD
Associate
Professor of Pediatrics, Neurology
and Radiology
Washington University School of Medicine,
St. Louis
New advances in recognition and treatment
of brain injury in the term born infant
Speaker Bio
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9:00am
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CIHR/IHDCYH LECTURER
Jacquetta M. Trasler,
MDCM, PhD
Associate
Director of Pediatrics, McGill University
Health Centre, Professor, Departments of Pediatrics,
Pharmacology & Therapeutics and Human Genetics,
McGill University
Importance of germline and early embryo DNA
methylation dynamics for normal fetal development
Speaker Bio
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10:00am
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BREAK
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10:30am
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RISING INVESTIGATORS
PRESENTATIONS
Michael House, MD
Assistant Professor of Obstetrics and Gynecology
Division of Maternal-Fetal Medicine
Tufts Medical Center
A
Multiscale Approach to Cervical Structural
Function During Pregnancy
Francine
H. Einstein, MD
Assistant Professor, Division of Maternal-
Fetal Medicine, Department of Obstetrics &
Gynecology and Women's Health
Montefiore Medical Center and the Albert
Einstein College of Medicine
Epigenetic modifications associated with
abnormal in utero fetal growth
Speaker Bio
Paul J. Rozance, MD
Assistant Professor of Pediatrics, Neonatal Medicine
University of Colorado Health Sciences Center
Glucose Replacement Leads to Fetal Hypoxia,
Acidosis, and Decreased Insulin Secretion in IUGR
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11:30 am
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NICHD Lecturer
Michael
Soares, PhD
University Distinguished Professor and Director
Institute of Maternal-Fetal Biology
Division of Cancer & Developmental Biology
Professor of Pathology & Laboratory Medicine
University of Kansas Medical Center
Uteroplacental Adaptations
Speaker Bio
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12:30pm
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LUNCH
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1:30pm - 3:30pm
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ACTIVITY
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4:00pm
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Business Meeting
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5:30pm
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MARCH OF DIMES LECTURER
Fred W. Turek,
PhD
Charles E. and
Emma H. Morrison Professor,
Director, Center for Sleep & Circadian Biology
Northwestern University
Dysregulation of circadian rhythms as sleep-
wake cycle: Impact on obesity, diabetes and
metabolic syndrome (even at a young age)
Speaker Bio
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6:30pm
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DINNER
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8:00pm
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Georgia O'Keefe Museum
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Sunday, Sept. 28
Event

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7:00am - 8:00am
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Young Investigators
Meeting
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7:00am - 8:00am
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BREAKFAST
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8:00am
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MEAD JOHNSON LECTURER
Jeff Neil, MD,
PhD
Allen & Josephine B. Green Professor of Neurology
Washington
University in St. Louis
Understanding brain injury in the preterm infant
Speaker Bio
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9:00am
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Pathik Wadhwa, MB, DS, PhD
Associate
Professor of Psychiatry & Human
Behavior, Obstetrics & Gynecology, and
Pediatrics
Director, Behavioral Perinatology/Development,
Health and Disease Research Program
University of California, Irvine
Stress in human pregnancy: biological
mediators and effects.
Speaker Bio
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10:00am
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Break
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10:30am
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Sam Mesiano, PhD
Assistant Professor of Reproductive Biology
and Physiology & Biophysics
Case Western Reserve University
Steroid hormone receptors and the physiology
of human birth timing
Speaker Bio
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11:00am
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Emmet Hirsch, MD
Associate Professor
Northwestern University
The role of toll-like receptor signaling in
infection-induced preterm labor
Speaker Bio
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11:30pm
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Adjourn
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11:45pm
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Box Lunch
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Speaker Bios
James M. Roberts, MD
Website:
http://institute.mwrif.org/viewpage.asp?siteID=0&pageID=547262
James
M. Roberts, M.D., is Professor of Obstetrics, Gynecology, and Reproductive
Sciences and Epidemiology at the University of Pittsburgh. His current
research include fundamental, clinical and health services approaches to the
understanding and management of adverse pregnancy outcomes. He leads an NIH
randomized controlled trial (10,000 women) of antioxidant vitamins to
prevent preeclampsia.
He has
received national and international recognition for this work. He was the
recipient of the lifetime achievement award for the study of hypertension in
pregnancy by the International Society for the Study of Hypertension in
Pregnancy and is the recipient of the 2008 Preeclampsia Foundation Hope
Award for Lifetime Achievement. He is the author of more than 200
publications. He serves or has served on the editorial boards of several
journals including, Placenta, Women’s Health Issues, Journal of Clinical
Endocrinology and Metabolism and Hypertension. He has served on
scientific review boards of the National Institutes of Health, the the
Canadian Institute for Health Research, the Food and Drug Administration and
the March of Dimes.
He was
the chair of the NICHD Maternal Fetal Medicine Network from 1990 –1999 and
is past president of the Perinatal Research Society, the North American
Society for the Study of Hypertension in Pregnancy, the Society of
Gynecological Investigation and the International Society for the Study of
Hypertension in Pregnancy. Dr. Roberts was formally admitted to fellowship
ad eundem of the Royal College of Obstetricians and Gynaecologists in
September of 2000. He has been elected to membership in Institute of
Medicine of the National Academy of Sciences.
He has
trained more than 60 MD and PhD investigators most of whom remain in
academic careers. He has been the principal investigator or program
director of three NIH programs funding young investigators. In
recognition of his achievements, he is the recipient of the NICHD 2004 Award
for Mentoring and the 2008 Society for Gynecological Investigation Frederick
Naftolin Award for Mentorship. He currently serves as mentor for several
junior faculty, postdoctoral fellows and medical students.
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Terrie
Inder, MD
Dr. Inder is an Associate Professor of Pediatrics,
Neurology, and Radiology as well as Neonatal Clinician at St. Louis
Children’s Hospital, Washington University. She is noted as author,
lecturer, and researcher for 63 peer reviewed manuscripts principally in the
field of neonatal neurology. She graduated with her Bachelor in Medicine
and Bachelor in Surgery from the University of Otago, Dunedin, New Zealand.
She completed her Residency in Pediatrics and Fellowship in Newborn
Medicine in New Zealand as well as her PhD in “Free Radical Mediated Injury
in the Newborn” before a second residency in child neurology at Children’s
Hospital in Boston. She now leads a strong research team at Washington
University in St Louis investigating the nature and timing of cerebral
injury and altered brain development in the preterm and term born infant.
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Jacquetta M. Trasler, MDCM,
PhD
Jacquetta
Trasler is a James McGill Professor of Pediatrics, Human Genetics and
Pharmacology & Therapeutics at McGill University and Associate Director for
Pediatric Research at the Research Institute of the McGill University Health
Centre (MUHC) in Montreal. She directs the Developmental Genetics Laboratory
at The Montreal Children’s Hospital Research Institute site of the MUHC and
teaches pharmacology and genetics to undergraduate, graduate and medical
students. At McGill, Dr. Trasler has mentored a number of pre-medical and
graduate students and directed the McGill University M.D./Ph.D. Program from
1999-2007.
As a scientist, Dr. Trasler’s research interests focus on epigenetics and
the molecular and developmental regulation of gene expression in the
germline with implications for the resulting embryos, with specific
interests in DNA methylation and genomic imprinting and the molecular and
cellular targets for drug effects on germ cells. As an independent
investigator, she has won several career awards including the Canadian
Institutes of Health Research (CIHR) Scientist Award; she is currently a
National Scholar of the Fonds de la recherche en santé du Québec. She was
also awarded the 2000 Prix d’Excellence for pediatric research from the
Inter-Service Clubs Council of Quebec and the 2001 Young Andrologist Award
from the American Society of Andrology. Her research is supported by several
grants from competitive funding agencies including the Canadian Institutes
of Health Research (Operating Grant and Strategic Initiative Programs) and
the National Institutes of Health (U.S.A.).
Dr. Trasler currently serves on the Editorial Boards of Biology of
Reproduction, Endocrinology, and the Journal of Andrology and is a member of
the Canadian Fertility and Andrology Society (and a Past-President), the
American Society of Andrology, the Society for the Study of Reproduction,
and the Endrocrine Society.
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Francine H. Einstein, MD
Website:
http://www.aecom.yu.edu/home/faculty/profile.asp?id=8540&O=1
Dr. Einstein’s primary research interests focus on the investigation of
obesity and maternal molecular metabolism and its impact on the fetus.
Specifically, she is studying the role of adipose tissue, particularly
visceral adipose tissue and nutrient excess in the pathogenesis of insulin
resistance in pregnancy and long-term effects of changes in maternal body
composition. In addition, she has been funded to investigate the effects of
abnormal intrauterine fetal growth on the genome-wide epigenetic profiles.
Epigenetic regulation, which allows for the stable propagation of gene
activation and inactivation, may serve as a biological memory of the
intrauterine environment. This valuable investigation may ultimately lead to
a better understanding of the mechanism of epigenetic changes in the setting
of abnormal fetal growth and the implicit roles that such changes play in
the development of adult-onset diseases, such as diabetes.
Dr. Einstein is the recipient of the American Association of Obstetricians &
Gynecologists Foundation and Society for Maternal-Fetal Medicine
Scholarship, a prestigious award to fund three consecutive years of research
training in maternal-fetal medicine. Dr. Einstein also has grant support
from the National Institutes of Health and the Albert Einstein College of
Medicine.
She is a Fellow of the American College of Obstetrics and Gynecology (ACOG)
and serves as a consultant for pregnant women with medical complications or
fetal abnormalities. Most recently, Dr. Einstein was awarded the Bernard
Zondek, MD Fellowship Award in Endocrinology for her work on insulin
resistance in pregnancy.
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Michael Soares, PhD
Professor Soares was born November 26,
1954 in Chico, California. He received his undergraduate training at
California State University, Chico where he received a B.A. degree in
Psychology in 1976. In 1981, Professor Soares completed his Ph.D. degree in
Reproductive Biology at the University of Hawaii, Honolulu in the laboratory
of Professor Joan C. Hoffmann. From 1981 to 1983, he received postdoctoral
training in endocrinology at the University of California, Santa Cruz under
the guidance of Professor Frank Talamantes. Additional postdoctoral training
in cell biology was obtained at Baylor College of Medicine under the
direction of Professor Stanley R. Glasser. A National Research Service Award
from the National Institutes of Health supported Professor Soares'
postdoctoral training. In 1984, Professor Soares was appointed as an
Assistant Professor in the Department of Physiology at the University of
Kansas Medical Center. He progressed through the academic ranks and in 1993
was promoted to the position of Professor of Physiology. In 2002, Dr. Soares
was appointed Director of the newly established Institute of Maternal-Fetal
Biology at the University of Kansas. In 2004, Dr. Soares moved to the
Department of Pathology and Laboratory Medicine at the University of Kansas
School of Medicine where he currently serves as Vice Chair and Director of
the Division of Cancer & Developmental Biology.
Professor Soares is internationally
recognized for his novel and innovative scientific achievements in the field
of molecular endocrinology and developmental biology. His laboratory is
actively investigating mechanisms underlying the control of cell
differentiation. These efforts include research on: 1) the regulation of
cell differentiation, especially as related to trophoblast stem cells, and
signaling pathways controlling their developmental fate; 2) species-specific
reproductive adaptations to physiological stressors; and 3) signaling events
involved in the establishment and maintenance of pregnancy; including
investigations on the prolactin gene family, intrauterine inflammatory and
immune cells, uterine vasculature, decidual cells, and the invasive
trophoblast cell lineage. Research from Professor Soares’ laboratory has
resulted in the generation of a number of valuable reagents that have been
shared with the research community.
For the past 23 years, Professor Soares'
research has been continuously supported by the National Institutes of
Health and has resulted in the publication of over 170 reports, including a
collection of outstanding comprehensive reviews of the field. Professor
Soares has served as a member of the editorial boards for the journals,
Biology of Reproduction, Trophoblast Research, Endocrinology, and Journal of
Endocrinology and on a National Institutes of Health Advisory panel in
Human Embryology and Development. He has also served the Society for the
Study of Reproduction as a member of the Program (1997, 1998, 2000, 2001,
2002), Publications (2001-2003), Stategic Planning (2003-2004), and
Nomination (2005-present) committees and the Endocrine Society as a member
of the Membership Committee (1998-2001). Professor Soares served as a Senior
Editor for the Journal of Endocrinology (2000-2005). Professor Soares
has been involved in organizing meetings on uteroplacental biology,
including a 1992 Serono-sponsored symposium on "Trophoblast Cells" held in
Las Vegas, Nevada, which formed the basis for a book edited by Professor
Soares and others. In 2006, Professor Soares co-edited a comprehensive
two-volume book entitled “Placenta and Trophoblast: Methods and
Protocols”. Professor Soares has been recognized for his research on
the placenta by the University of Kansas School of Medicine with a Faculty
Research Award in 1989, by the University of Tokyo with a Distinguished
Visiting Scientist Award in 1994, by the European Placental Group with the
Adriana and Luisa Castellucci Award Lecture in 1995, with a lecture at the
Presidential Symposium during the Annual Meeting of the Society for the
Study of Reproduction in 1997, and the University of Kansas Chancellor's
Club Research Award in 2001 and Higuchi Research Achievement Award in 2004.
Professor Soares was appointed as a University Distinguished Professor of
the University of Kansas in 2007.
Professor Soares has also directly
supervised the training of twenty-eight postdoctoral fellows and eight
graduate students, served as Director of an NIH-sponsored training program
in Reproductive Biology (1996-2000), and is currently Program Director of an
NIH supported BIRCWH K12 Faculty Development Program in women’s health
research.
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Fred W. Turek, PhD
Website:
http://www.northwestern.edu/neurobiology/faculty/turek.html
Fred W. Turek, PhD received his
undergraduate degree in the biological sciences from Michigan State
University in 1969, and his PhD from Stanford University in 1973 where he
carried out research on circadian and seasonal rhythms. After postdoctoral
training at the University of Texas at Austin, he took a faculty position at
Northwestern University where he served as the Chair of the Department of
Neurobiology & Physiology from 1987-98. Dr. Turek is the founder and current
Director of the Center for Sleep and Circadian Biology at Northwestern
University. Dr. Turek was the founding president of the Society for Research
on Biological Rhythms (SRBR) and served in this capacity for six years. He
was the Editor-in-Chief of the Journal of Biological Rhythms from 1995-2000.
He is presently a Deputy Editor of the journal Sleep. He has served on a
number of government advisory bodies and his research on biological rhythms
has been supported by the National Institutes of Health, the National
Science Foundation, NASA, the Air Force Office of Scientific Research, the
Army Research Office, DARPA, as well as a number of private foundations and
pharmaceutical companies. He has received a number of awards in recognition
of his academic and research achievements, including an NIH Research Career
Development Award, two Senior International Fogarty Fellowships from the NIH,
a Guggenheim Memorial Foundation Fellowship and a Distinguished Investigator
Award from the National Alliance for Research on Schizophrenia and
Depression (NARSAD). Dr. Turek has served on the Board of the NIH National
Center on Sleep Disorders Research and on the Board of the National Sleep
Foundation. Dr. Turek’s present research interests are on the genetic,
molecular and neural basis for sleep and circadian rhythms with a special
interest on the relationship between the sleep and circadian clock systems
with energy balance and metabolic diseases. His laboratory is working with a
number of different animal models for aging, as well as the effects of sleep
loss and circadian disruption on health, mental and physical health, and he
has published over 285 full length papers.
Dr. Turek is presently the Charles E. and Emma H. Morrison Professor of
Biology and he is the founder and director of the Center for Sleep and
Circadian Biology at Northwestern University.
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to Top
Jeff Neil, MD, PhD
Jeff Neil, MD, PhD attended Washington
University in St. Louis for his
undergraduate and postgraduate training. He is a Pediatric Neurologist
with a PhD in Neuroscience. He holds the Allen P. and Josephine B.
Green Chair in Neurology. He is a practicing Pediatric Neurologist with
has faculty appointments in Neurology, Pediatrics, Radiology and the
Division of Biology and Biomedical Sciences. Dr. Neil's research is
centered around the application of MRI methods to brain development and
injury.
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Pathik
Wadhwa, MB, DS, PhD
Pathik D. Wadhwa, M.D., Ph.D., is
an Associate Professor at the University of California, Irvine, School of
Medicine, with academic appointments in the Departments of Psychiatry &
Human Behavior, Obstetrics & Gynecology, and Pediatrics. Dr. Wadhwa also is
Director of the UC Irvine Behavioral Perinatology/ Development, Health and
Disease Research Program. Dr. Wadhwa received his medical degree from the
University of Poona, India, in 1985 and his doctorate in health psychology/
behavioral medicine from the University of California, Irvine, in 1993. Dr.
Wadhwa’s research examines the interface between behavioral and biological
processes in human pregnancy, with an emphasis on outcomes related to fetal
development, birth and subsequent infant and child development and health.
In particular, this work focuses on the interplay between
maternal-placental-fetal neuroendocrine, immune/ inflammatory and
maternal-fetal genetic processes as putative mechanisms that mediate the
effects of the maternal environment (and particularly prenatal stress) on
early human development. Dr. Wadhwa’s work is supported by several federal
research grants from the National Institutes of Health, including a program
project on gene-environment interactions in human parturition. Dr. Wadhwa
also is the Co-Principal Investigator of the National Children’s Study (NCS)
Orange County, California (OCCA) Vanguard Center. Dr. Wadhwa is the
recipient of several national honors and awards, including recognition for
his early career contributions from the Academy of Behavioral Medicine.
The research studies conducted by Dr. Wadhwa and his colleagues support a
significant and independent role for maternal psychosocial stress during
pregnancy in the etiology of prematurity-related outcomes, and suggest that
these effects are mediated, in part, by the maternal-placental-fetal
neuroendocrine axis, and specifically by the placental hormone
corticotrophin-releasing factor. These studies also provide evidence to
support the notion that the influence of maternal prenatal stress and
maternal-placental hormones on the developing fetus may persist after birth,
as assessed by measures of temperament and behavioral reactivity in infancy
and childhood. Last, recent studies conducted by Dr. Wadhwa and colleagues
suggest that exposure to high levels of prenatal stress may produce
long-term alterations in key endocrine, immune and metabolic processes that
persist till adult life.
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Sam Mesiano,
PhD
Website:
http://www.case.edu/med/reprobiol/mesiano.html
Sam Mesiano
received a PhD in Physiology in 1988 at Monash University, Australia. His
dissertation research involved a detailed study of the role of IGFs in the
hormonal control of growth in the fetal lamb. Dr Mesiano was then awarded a
WM Keck postdoctoral fellowship in molecular endocrinology in the laboratory
of Dr Robert Jaffe in the Reproductive Endocrinology Center at the
University of California, San Francisco where he studied the development and
functional biology of the human fetal adrenal cortex. After completing a
postdoctoral fellowship he remained at UCSF as a staff scientist (1992-1995)
and then faculty member until 1998. During that time he was a
co-investigator on 2 NIH-funded grants and co-supervised 12 Reproductive
Endocrinology/Infertility fellows. His studies were in the areas of 1)
human fetal adrenal development and function, 2) the control of angiogenesis
in the human fetus, the adult female reproductive tract and in the
progression of ovarian cancer, and 3) the role of phytoestrogens in the
regulation of adrenal steroidogenesis. In 1998 Dr Mesiano moved to the
University of Newcastle, Australia where he was a principal investigator in
the Mothers and Babies Research Centre with funding from the National Health
and Medical Research Council of Australia. During his tenure at the
University of Newcastle Dr Mesiano continued to study the role of steroid
hormones in the control of human pregnancy and parturition. In 2004 he left
Newcastle to take up a faculty position in the Department of Reproductive
Biology at CWRU where he continues to explore the hormonal control of human
parturition.
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Emmet Hirsch, MD
Emmet Hirsch, MD is Director of the Division of
Obstetrics in the Department of Obstetrics and Gynecology at Evanston
Northwestern Healthcare, and an Associate Professor of Obstetrics and
Gynecology at Northwestern University Medical School.
Dr. Hirsch graduated from the Honors Program in Medical
Education at Northwestern University Medical School in 1988, where he was
awarded membership in the AOA medical honors society. He then completed a
four-year residency in Obstetrics and Gynecology at Prentice Women’s
Hospital and Northwestern University.
In 1992, Dr. Hirsch began a four-year post-doctoral
research fellowship in the department of Biochemistry and Molecular
Biophysics at Columbia University in New York, where he acquired advanced
training in molecular biological techniques. After his fellowship, Dr.
Hirsch remained at Columbia as an Assistant Professor until his transfer to
the Chicago area.
Dr. Hirsch’s research focuses on infectious and
inflammatory processes in reproduction, with a special emphasis on the
molecular pathophysiology of infection-induced preterm labor. In addition to
his administrative and research responsibilities, Dr. Hirsch maintains a
clinical practice and is active in resident, medical student and graduate
student training. Dr. Hirsch’s wife, Arica, is a graduate of Northwestern
University Medical School. She was chief resident in Radiation Oncology at
Memorial Sloan-Kettering Cancer Center in New York and currently practices
in Chicago. They have four children.
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Additional information regarding speakers will be posted as it becomes available. Please feel free to contact Anthony R. Gregg, MD
via email at prs@med.sc.edu if you have any questions.
Click
here for the PRS Reimbursement Policies.
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